Marcotte EM and Tsechansky M (2009) Disorder, promiscuity, and toxic partnerships. Cell 138(1):16-8
Abstract: Many genes are toxic when overexpressed, but general mechanisms for this toxicity have proven elusive. Vavouri et al. (2009) find that intrinsic protein disorder and promiscuous molecular interactions are strong determinants of dosage sensitivity, explaining in part the toxicity of dosage-sensitive oncogenes in mice and humans.
|Status: Published||Type: Comment | Journal Article||PubMed ID: 19596229|
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