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Burke DJ (2009) Interpreting spatial information and regulating mitosis in response to spindle orientation. Genes Dev 23(14):1613-8
Abstract: The spindle position checkpoint (SPOC) is a regulatory mechanism that ensures accurate segregation of chromosomes in polarized cells during mitosis. In this issue of Genes & Development, Chan and Amon (pp. 1639-1649) identify a phosphoprotein phosphatase (Rts1-PP2A) as a new member of the checkpoint in budding yeast and define its role in interpreting spatial information during mitosis.
| Status: Published | Type: Comment | Journal Article | PubMed ID: 19605682 |
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