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Sezen B, et al.  (2009) The SESA network links duplication of the yeast centrosome with the protein translation machinery. Genes Dev 23(13):1559-70

Abstract: The yeast spindle pole body (SPB), the functional equivalent of mammalian centrosome, duplicates in G1/S phase of the cell cycle and then becomes inserted into the nuclear envelope. Here we describe a link between SPB duplication and targeted translation control. When insertion of the newly formed SPB into the nuclear envelope fails, the SESA network comprising the GYF domain protein Smy2, the translation inhibitor Eap1, the mRNA-binding protein Scp160 and the Asc1 protein, specifically inhibits initiation of translation of POM34 mRNA that encodes an integral membrane protein of the nuclear pore complex, while having no impact on other mRNAs. In response to SESA, POM34 mRNA accumulates in the cytoplasm and is not targeted to the ER for cotranslational translocation of the protein. Reduced level of Pom34 is sufficient to restore viability of mutants with defects in SPB duplication. We suggest that the SESA network provides a mechanism by which cells can regulate the translation of specific mRNAs. This regulation is used to coordinate competing events in the nuclear envelope.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19571182

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ASC1 BBP1 BFR1 BRE5 CDC33 EAP1 GCN4 MLP1 MLP2 MPS2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
NDC1 NIP1 PGK1 POM152 POM34 POP2 RPL35A RPL35B SCP160 SEC61
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball
Protein-Nucleic Acid Interactions blue ball
Protein-protein Interactions blue ball
Regulation of blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball
Translational Regulation blue ball

Topics Genes linked to topics (#21 )
SMY2
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Protein Physical Properties blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball
Strains/Constructs blue ball

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