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Pinson B, et al.  (2009) Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways. Genes Dev 23(12):1399-407

Abstract: Cells use strategic metabolites to sense the metabolome and accordingly modulate gene expression. Here, we show that the purine and phosphate pathways are positively regulated by the metabolic intermediate AICAR (5'-phosphoribosyl-5-amino-4-imidazole carboxamide). The transcription factor Pho2p is required for up-regulation of all AICAR-responsive genes. Accordingly, the binding of Pho2p to purine and phosphate pathway gene promoters is enhanced upon AICAR accumulation. In vitro, AICAR binds both Pho2p and Pho4p transcription factors and stimulates the interaction between Pho2p and either Bas1p or Pho4p in vivo. In contrast, SAICAR (succinyl-AICAR) only affects Pho2p-Bas1p interaction and specifically up-regulates purine regulon genes. Together, our data show that Bas1p and Pho4p compete for Pho2p binding, hence leading to the concerted regulation of cellular nucleotide synthesis and phosphate consumption.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 19528318

Topics addressed in this paper

Number of different genes curated to this paper: 57

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Topics Genes linked to topics (#1 - 10 )
ADE1 ADE12 ADE13 ADE16 ADE17 ADE2 ADE3 ADE4 ADE5,7 ADE6
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Topics Genes linked to topics (#11 - 20 )
ADE8 BAS1 BDH1 BNA2 BNA4 CEM1 CIT2 FCY21 GCV1 GCV2
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Topics Genes linked to topics (#21 - 30 )
GCV3 GSY1 HIS1 HIS4 HIS5 HPT1 HXT6 HXT7 INO1 ITR1
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Topics Genes linked to topics (#31 - 40 )
MAE1 MTD1 MUP3 OPI3 OPT2 PHM6 PHO11 PHO12 PHO2 PHO4
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Topics Genes linked to topics (#41 - 50 )
PHO5 PHO81 PHO84 PHO89 SAM3 SER1 SER2 SHM2 SNF2 SPL2
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Topics Genes linked to topics (#51 - 57 )
VIP1 VTC1 VTC3 VTC4 YDL241W YJL045W ZRT1
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