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Burston HE, et al.  (2009) Regulators of yeast endocytosis identified by systematic quantitative analysis. J Cell Biol 185(6):1097-110

Abstract: Endocytosis of receptors at the plasma membrane is controlled by a complex mechanism that includes clathrin, adaptors, and actin regulators. Many of these proteins are conserved in yeast yet lack observable mutant phenotypes, which suggests that yeast endocytosis may be subject to different regulatory mechanisms. Here, we have systematically defined genes required for internalization using a quantitative genome-wide screen that monitors localization of the yeast vesicle-associated membrane protein (VAMP)/synaptobrevin homologue Snc1. Genetic interaction mapping was used to place these genes into functional modules containing known and novel endocytic regulators, and cargo selectivity was evaluated by an array-based comparative analysis. We demonstrate that clathrin and the yeast AP180 clathrin adaptor proteins have a cargo-specific role in Snc1 internalization. We additionally identify low dye binding 17 (LDB17) as a novel conserved component of the endocytic machinery. Ldb17 is recruited to cortical actin patches before actin polymerization and regulates normal coat dynamics and actin assembly. Our findings highlight the conserved machinery and reveal novel mechanisms that underlie endocytic internalization.

Status: Published Type: Journal Article PubMed ID: 19506040

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Number of different genes curated to this paper: 63

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ABP1 ADE12 AIM21 AIP1 APL1 ARC18 ATG20 BBC1 BZZ1 CAP1
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CAP2 CHC1 CHO2 CLC1 CRN1 DEP1 DFG16 DID2 EDE1 END3
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ENT1 ERG3 FUS3 INO1 INP52 LDB17 LSB3 MYO5 OPI3 OPI9
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Topics Genes linked to topics (#31 - 40 )
PKH2 RIM101 RIM20 RIM21 RIM8 RIM9 RPL16B RPL19B RRT16 RVS161
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RVS167 SAC6 SHE4 SLA1 SNC1 SNF8 SNX4 SRN2 SSO1 STE6
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STP22 SYP1 TPM1 TWF1 UME6 VPS36 VRP1 YAP1801 YAP1802 YGR122W
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Topics Genes linked to topics (#61 - 63 )
YNR005C YOL098C YSC84
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