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Zou J, et al.  (2009) Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae. Mol Biol Cell 20(14):3239-50

Abstract: Monitoring Editor: Fred Chang In the budding yeast S. cerevisiae, the G1-specific Cdks Cln1,2-Cdc28 and Pcl1,2-Pho85 are essential for ensuring that DNA replication and cell division are properly linked to cell polarity and bud morphogenesis. However, the redundancy of Cdks and cyclins means that identification of relevant Cdk substrates remains a significant challenge. We used array-based genetic screens (synthetic genetic array or SGA analysis) to dissect redundant pathways associated with G1 cyclins and identified Bni4 as a substrate of the Pcl1- and Pcl2-Pho85 kinases. BNI4 encodes an adaptor protein that targets several proteins to the bud neck. Deletion of BNI4 results in severe growth defects in the absence of the Cdc28 cyclins Cln1 and Cln2, and overexpression of BNI4 is toxic in yeast cells lacking the Pho85 cyclins Pcl1 and Pcl2. Phosphorylation of Bni4 by Pcl-Pho85 is necessary for its localization to the bud neck, and the bud neck structure can be disrupted by overexpressing BNI4 in pcl1Deltapcl2Delta mutant cells. Our data suggest that misregulated Bni4 may bind in an uncontrolled manner to an essential component that resides at the bud neck causing catastrophic morphogenesis defects.

Status: Published Type: Journal Article PubMed ID: 19458192

Topics addressed in this paper

Number of different genes curated to this paper: 92

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Topics Genes linked to topics (#1 - 10 )
AIM44 APL3 AXL1 BCK1 BEM1 BEM2 BNI1 BNI4 BNR1 BOI1
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Topics Genes linked to topics (#11 - 20 )
BOP3 BUD22 BUD3 BUD4 CDC10 CDC11 CDC12 CDC28 CDC42 CDC55
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Topics Genes linked to topics (#21 - 30 )
CDH1 CHS3 CLA4 CLN1 CLN2 CLN3 CMD1 CTK1 CYK3 EMC1
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Topics Genes linked to topics (#31 - 40 )
EXO84 FRT2 GET1 GET2 GIN4 HOF1 HOS3 HPC2 HSL1 HSL7
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Topics Genes linked to topics (#41 - 50 )
IQG1 KEL1 LGE1 LSM1 MMS22 MNN10 MPS1 MSN5 MYO1 MYO2
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Topics Genes linked to topics (#51 - 60 )
MYO4 NAP1 NBP2 NGR1 PAC10 PCL1 PCL2 PCL6 PHO5 PHO85
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Topics Genes linked to topics (#61 - 70 )
PKC1 PMR1 PXL1 QRI1 RAD27 REG2 RGA2 RTF1 RVS161 SAC3
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Topics Genes linked to topics (#71 - 80 )
SAP30 SAT4 SCS2 SEC22 SGF73 SHS1 SKG3 SKT5 SLT2 SSD1
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Topics Genes linked to topics (#81 - 90 )
SST2 SWI4 SYP1 TIM12 VMA2 VPS21 YCR051W YDL073W YER085C YNL035C
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Topics Genes linked to topics (#91 - 92 )
YRF1-1 ZRG8
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