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Ungar L, et al.  (2009) A genome-wide screen for essential yeast genes that affect telomere length maintenance. Nucleic Acids Res 37(12):3840-9

Abstract: Telomeres are structures composed of repetitive DNA and proteins that protect the chromosomal ends in eukaryotic cells from fusion or degradation, thus contributing to genomic stability. Although telomere length varies between species, in all organisms studied telomere length appears to be controlled by a dynamic equilibrium between elongating mechanisms (mainly addition of repeats by the enzyme telomerase) and nucleases that shorten the telomeric sequences. Two previous studies have analyzed a collection of yeast deletion strains (deleted for nonessential genes) and found over 270 genes that affect telomere length (Telomere Length Maintenance or TLM genes). Here we complete the list of TLM by analyzing a collection of strains carrying hypomorphic alleles of most essential genes (DAmP collection). We identify 87 essential genes that affect telomere length in yeast. These genes interact with the nonessential TLM genes in a significant manner, and provide new insights on the mechanisms involved in telomere length maintenance. The newly identified genes span a variety of cellular processes, including protein degradation, pre-mRNA splicing and DNA replication.

Status: Published Type: Journal Article PubMed ID: 19386622

Topics addressed in this paper

Number of different genes curated to this paper: 91

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAR2 ALA1 APC4 ARC15 ARC35 ARP2 ARP3 BBP1 CBF5 CDC13
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Large-scale phenotype analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
CDC16 CDC19 CDC34 CDC36 CMD1 COG3 DAD2 FAL1 FCP1 GCD1
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Topics Genes linked to topics (#21 - 30 )
GPI8 HEM4 HRT1 ILV5 KRS1 LSM8 MCD4 MCM3 MCM6 MDN1
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Topics Genes linked to topics (#31 - 40 )
MTR3 NAM9 NCP1 NET1 NHP2 NOC4 NTR2 ORC5 PIF1 POP7
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Topics Genes linked to topics (#41 - 50 )
PRE2 PRE5 PRI1 PRP22 PRP31 PRP38 PRP4 PRP43 PSF3 RGR1
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Topics Genes linked to topics (#51 - 60 )
RIF1 RIF2 RNA14 RNA15 RPB5 RPB7 RPN12 RPN5 RPN6 RPN7
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Topics Genes linked to topics (#61 - 70 )
RPS31 RPT3 RPT5 RSC4 RSC8 SAD1 SAH1 SAM35 SEC20 SEC63
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Topics Genes linked to topics (#71 - 80 )
SEN54 SMT3 SPN1 STN1 TBF1 TEL1 TID3 TRS20 TRS23 TSR1
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Topics Genes linked to topics (#81 - 90 )
TUB2 XRS2 YDL163W YDR396W YJL032W YLR198C YLR230W YLR317W YLR339C YOR218C
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Topics Genes linked to topics (#91 )
YPP1
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