Gartenberg MR (2009) Life on the edge: telomeres and persistent DNA breaks converge at the nuclear periphery. Genes Dev 23(9):1027-31
Abstract: Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein that spans the inner nuclear membrane. Anchorage maintains telomere integrity and steers double-strand breaks toward specialized repair pathways. This work defines the nuclear periphery as a subcompartment where dangerous DNA elements can be handled with care.
|Status: Published||Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't||PubMed ID: 19417100|
Topics addressed in this paper
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