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Mak HC, et al.  (2009) Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Res 19(6):1014-25

Abstract: Transcription factors are most commonly thought of as proteins that regulate expression of specific genes, independently of the order of those genes along the chromosome. By screening genome-wide chromatin immunoprecipitation (ChIP) profiles in yeast, we find that more than 10% of DNA-binding transcription factors concentrate at the subtelomeric regions near to chromosome ends. None of the proteins identified were previously implicated in regulation at telomeres, yet genomic and proteomic studies reveal that a subset of factors show many interactions with established telomere binding complexes. For many factors, the subtelomeric binding pattern is dynamic and undergoes flux toward or away from the telomere as physiological conditions shift. We find that subtelomeric binding is dependent on environmental conditions and correlates with the induction of gene expression in response to stress. Taken together, these results underscore the importance of genome structure in understanding the regulatory dynamics of transcriptional networks.

Status: Published Type: Journal Article PubMed ID: 19372386

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD3 ADH7 AFT2 CUP9 DAL80 DAT1 GAL4 GAT3 GIT1 GZF3
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HAP4 HMLALPHA1 HMLALPHA2 HMRA1 HMRA2 MAL33 MET18 MIG1 MSN4 NRG1
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PAU1 PAU11 PAU13 PAU15 PAU16 PAU20 PAU21 PAU22 PAU4 PAU6
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PDR1 PHD1 PHO89 PUG1 RAP1 RDS1 RGM1 ROX1 UGA3 XBP1
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YAP5 YAP6 YCR102C YER184C YJL206C YLR460C YML131W YMR315W YNR068C YPR196W
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