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Alberti S, Halfmann R, King O, Kapila A, Lindquist S  (2009) A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell 137(1):146-58

Abstract: Prions are proteins that convert between structurally and functionally distinct states, one or more of which is transmissible. In yeast, this ability allows them to act as non-Mendelian elements of phenotypic inheritance. To further our understanding of prion biology, we conducted a bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae, followed by experimental investigations of 100 prion candidates. We found an unexpected amino acid bias in aggregation-prone candidates and discovered that 19 of these could also form prions. At least one of these prion proteins, Mot3, produces a bona fide prion in its natural context that increases population-level phenotypic heterogeneity. The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. PubMed ID: 19345193

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Topics Genes linked to topics (#1 - 10 )
AIM3 AKL1 ASM4 AZF1 CAF40 CBK1 CCR4 CLA4 CYC8 DDR48
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DEF1 ENT1 ENT2 EPL1 GAL11 GLN3 GPR1 GTS1 HRP1 HRR25
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HSP104 JSN1 KSP1 LSM4 MCA1 MCM1 MED2 MOT3 MRN1 MSS11
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Topics Genes linked to topics (#31 - 40 )
NAB2 NAB3 NEW1 NGR1 NRD1 NRP1 NSP1 NUP100 NUP116 NUP42
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Topics Genes linked to topics (#41 - 50 )
NUP49 NUP57 PAN1 PCF11 PDC2 PDR1 PEX13 PGD1 PIN3 POP2
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Topics Genes linked to topics (#51 - 60 )
PSP1 PSP2 PUB1 PUF2 PUF4 RAT1 RBS1 RGT1 RIM4 RLM1
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Topics Genes linked to topics (#61 - 70 )
RNQ1 SAP30 SCD5 SCD6 SGF73 SIN3 SKG3 SKG6 SLA2 SLM1
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SNF2 SNF5 SOK2 SSD1 SUP35 SWI1 TAF12 TIF4631 TIF4632 UPC2
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URE2 VTS1 WWM1 YAK1 YAP1802 YBL081W YBR016W YCK1 YLR177W YMR124W
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Topics Genes linked to topics (#91 )
YPR022C
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