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Kirmizis A, et al.  (2009) Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2. Nat Struct Mol Biol 16(4):449-51

Abstract: Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (i) H3R2me1 does not inhibit histone H3 Lys4 (H3K4) methylation; (ii) it is present throughout the coding region of genes; and (iii) it correlates with active transcription. Collectively, these results indicate that different H3R2 methylation states have defined roles in gene expression.

Status: Published Type: Journal Article PubMed ID: 19270702

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
BRE2 ECM19 HHF2 HHT1 HHT2 HOP1 PMT2 SDC1 SET1 SHG1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Genomic co-immunoprecipitation study yg ball
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Omics yg ball
Primary Literature blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball
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Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 15 )
SPP1 SPR3 SWD1 SWD2 SWD3
Additional Literature blue ball blue ball blue ball blue ball
Primary Literature blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball
Regulation of blue ball
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