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Fiedler D, et al.  (2009) Functional organization of the S. cerevisiae phosphorylation network. Cell 136(5):952-63

Abstract: Reversible protein phosphorylation is a signaling mechanism involved in all cellular processes. To create a systems view of the signaling apparatus in budding yeast, we generated an epistatic miniarray profile (E-MAP) comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators. Quantitative genetic interaction mapping reveals factors working in compensatory pathways (negative genetic interactions) or those operating in linear pathways (positive genetic interactions). We found an enrichment of positive genetic interactions between kinases, phosphatases, and their substrates. In addition, we assembled a higher-order map from sets of three genes that display strong interactions with one another: triplets enriched for functional connectivity. The resulting network view provides insights into signaling pathway regulation and reveals a link between the cell-cycle kinase, Cak1, the Fus3 MAP kinase, and a pathway that regulates chromatin integrity during transcription by RNA polymerase II.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, Non-P.H.S. PubMed ID: 19269370

Topics addressed in this paper

Number of different genes curated to this paper: 48

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADO1 ARG82 BUB1 BUD14 CAK1 CLA4 CLB2 CTK1 CTK2 EAF3
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Computational analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
ELP2 ELP3 FLO8 FUS3 GCN2 HAL5 HOG1 HTZ1 IPK1 KCS1
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Topics Genes linked to topics (#21 - 30 )
NBP2 PBS2 PLC1 PPH21 PPH22 PPH3 PTC1 PTC2 PTC3 PTK2
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Topics Genes linked to topics (#31 - 40 )
PTP2 PTP3 SAP155 SAT4 SET2 SGV1 SIT4 SMK1 SNF1 SSK1
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Topics Genes linked to topics (#41 - 48 )
SSK2 SSK22 STE20 SWR1 VIP1 VPS71 VPS72 YPD1
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