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Hontz RD, et al.  (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19

Abstract: Ribosomal RNA (rRNA) is transcribed from the ribosomal DNA (rDNA) genes by RNA polymerase I (Pol I). Despite being responsible for the majority of transcription in growing cells, Pol I regulation is poorly understood compared to Pol II. To gain new insights into rDNA transcriptional regulation, we developed a genetic assay in Saccharomyces cerevisiae that detects alterations in transcription from the centromere-proximal rDNA gene of the tandem array. Changes in Pol I transcription at this gene alter the expression of an adjacent, modified URA3 reporter cassette (mURA3), such that reductions in Pol I transcription induce growth on synthetic media lacking uracil. Increases in Pol I transcription induce growth on media containing 5-FOA. A transposon mutagenesis screen was performed with the reporter strain to identify genes that play a role in modulating rDNA transcription. Mutations in 68 different genes were identified, several of which were already known to function in chromatin modification and the regulation of Pol II transcription. Among the other classes of genes were those encoding proteasome subunits and multiple kinases and phosphatases that function in nutrient and stress signaling pathways. Fourteen genes were previously uncharacterized and have been named as Regulators of rDNA Transcription (RRT).

Status: Published Type: Journal Article PubMed ID: 19270272

Topics addressed in this paper

Number of different genes curated to this paper: 88

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Topics Genes linked to topics (#1 - 10 )
AAP1 ADA2 AGC1 ATG2 BNI4 BRE1 CHD1 CHS6 CIN1 CMP2
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Topics Genes linked to topics (#11 - 20 )
DAS2 DPB11 ECM29 FUR4 GAP1 GCN5 GPB1 GPG1 GPM3 GUT2
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Topics Genes linked to topics (#21 - 30 )
HFI1 HMS1 HOS1 HOS2 HOS3 IMP2' INM1 IRA1 IRA2 MER1
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Topics Genes linked to topics (#31 - 40 )
MLC2 MLP1 MNN1 MSS4 NTE1 NTS1-1 NTS1-2 PAF1 PAU7 PHO23
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Topics Genes linked to topics (#41 - 50 )
PIG2 PPH22 PRE9 PRR1 PSK2 PXL1 RAD6 RCO1 RDN1 RED1
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Topics Genes linked to topics (#51 - 60 )
REV3 RPA135 RPD3 RPN7 RPN8 RRN5 RRT1 RRT12 RRT13 RRT14
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Topics Genes linked to topics (#61 - 70 )
RRT15 RRT16 RRT2 RRT5 RRT6 RRT7 RRT8 RSC1 RTC2 RXT3
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Topics Genes linked to topics (#71 - 80 )
SAC7 SAP30 SBA1 SET1 SET2 SEY1 SIN3 SIR1 SIR2 SPT20
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Topics Genes linked to topics (#81 - 88 )
UAF30 UME1 UME6 URA5 URA6 URC2 YPK1 ZIP2
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