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Tan SX, et al.  (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20(5):1493-508

Abstract: Monitoring Editor: Sean Munro Genome-wide screening for sensitivity to chronic endoplasmic reticulum (ER) stress induced by dithiothreitol and tunicamycin identified mutants deleted for Cu, Zn superoxide dismutase function (SOD1, CCS1) or affected in NADPH generation via the pentose phosphate pathway (TKL1, RPE1). Tunicamycin-induced ER stress led to an increase in cellular superoxide accumulation and an increase in SOD1 expression and Sod1p activity. Prior adaptation of the hac1 mutant deficient in the unfolded protein response (UPR) to the superoxide-generating agent paraquat reduced cell death under ER stress. Overexpression of the ER oxidoreductase Ero1p known to generate hydrogen peroxide in vitro, did not lead to increased superoxide levels in cells subjected to ER stress. The mutants lacking SOD1, TKL1 or RPE1 exhibited decreased UPR induction under ER stress. Sensitivity of the sod1 mutant to ER stress and decreased UPR induction was partially rescued by overexpression of TKL1 encoding transketolase. These data indicate an important role for superoxide dismutase and cellular NADP(H) in cell survival during ER stress and it is proposed that accumulation of superoxide affects NADP(H) homeostasis leading to reduced UPR induction during ER stress.

Status: Published Type: Journal Article PubMed ID: 19129474

Topics addressed in this paper

Number of different genes curated to this paper: 89

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAT2 ADO1 AIM26 ALG7 ARO2 BCK1 BUR2 CCS1 CNB1 CNM67
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Topics Genes linked to topics (#11 - 20 )
CRZ1 CSG2 ELP2 ERG2 ERG6 ERO1 ERV29 FLD1 GEP4 GET1
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Topics Genes linked to topics (#21 - 30 )
GLR1 GND1 GTR1 GYP1 HAC1 HYR1 IES2 IES6 IRE1 KCS1
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Topics Genes linked to topics (#31 - 40 )
KIN3 KRE6 LHS1 LYS9 MON2 NUP188 NUP84 OCA6 OLA1 OPI9
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Topics Genes linked to topics (#41 - 50 )
OST3 PAF1 PEP12 PEP3 PGD1 PMR1 REG1 RLM1 ROT2 ROX3
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Topics Genes linked to topics (#51 - 60 )
RPE1 RPL12A RPL24B RPL37A SAC1 SAC7 SET3 SHP1 SIN4 SIW14
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Topics Genes linked to topics (#61 - 70 )
SLT2 SOD1 SOD2 SPF1 STE20 STF1 SWI6 TCB3 TDA5 TKL1
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Topics Genes linked to topics (#71 - 80 )
UBP14 VMA13 VMA21 VPH2 VPS1 VPS20 VPS27 VPS33 VPS34 VPS41
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Topics Genes linked to topics (#81 - 89 )
VPS45 VPS54 VPS64 VPS8 VPS9 XRS2 YAP1 YAP3 YPT7
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