Jin Y, et al. (2009) PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex. Mol Biol Cell 20(5):1312-23
Abstract: Monitoring Editor: Janet M. Shaw Organelle inheritance occurs during cell division. In S. cerevisiae, inheritance of the vacuole, and the distribution of mitochondria and cortical endoplasmic reticulum are regulated by Ptc1p, a type 2C protein phosphatase. Here we show that PTC1/VAC10 controls the distribution of additional cargoes moved by a myosin-V motor. These include peroxisomes, secretory vesicles, cargoes of Myo2p, and ASH1 mRNA, a cargo of Myo4p. We find that Ptc1p is required for the proper distribution of both Myo2p and Myo4p. Surprisingly, PTC1 is also required to maintain the steady-state levels of organelle-specific receptors, including Vac17p, Inp2p and Mmr1p, which attach Myo2p to the vacuole, peroxisomes and mitochondria, respectively. Furthermore, Vac17p fused to the cargo-binding domain of Myo2p suppressed the vacuole inheritance defect in ptc1Delta cells. These findings suggest that PTC1 promotes the association of myosin-V with its organelle-specific adaptor proteins. Moreover, these observations suggest that despite the existence of organelle-specific receptors, there is a higher order regulation that coordinates the movement of diverse cellular components.
|Status: Published||Type: Journal Article||PubMed ID: 19116310|
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