Kniewel R and Keeney S (2009) Histone methylation sets the stage for meiotic DNA breaks. EMBO J 28(2):81-3
Abstract: Covalent post-translational modifications of histones have important functions in transcription, replication, repair, and other aspects of eukaryotic chromosome dynamics. Trimethylation of lysine-4 on histone H3 is enriched at actively transcribed loci in many organisms. The impact of this histone modification on transcription has been extensively studied, but less is known about its effects on other chromosomal processes. An intriguing new study in this issue of EMBO Journal demonstrates that H3 lysine-4 trimethylation is critical in budding yeast for formation of the programmed DNA double-strand breaks that initiate homologous recombination during meiosis. These findings have important implications for elucidating the previously recognized but little understood connections between meiotic break formation and transcriptional promoters in this organism.
|Status: Published||Type: Comment | Journal Article | Research Support, Non-U.S. Gov't||PubMed ID: 19158660|
Topics addressed in this paper
Number of different genes curated to this paper: 2
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.