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Bengtsson O, et al.  (2008) Identification of common traits in improved xylose-growing Saccharomyces cerevisiae for inverse metabolic engineering. Yeast 25(11):835-47

Abstract: Four recombinant Saccharomyces cerevisiae strains with enhanced xylose growth (TMB3400, C1, C5 and BH42) were compared with two control strains (TMB3399, TMB3001) through genome-wide transcription analysis in order to identify novel targets for inverse metabolic engineering. A subset of 13 genes with changed expression levels in all improved strains was selected for further analysis. Thirteen validation strains and two reference strains were constructed to investigate the effect of overexpressing or deleting these genes in xylose-utilizing S. cerevisiae. Improved aerobic growth rates on xylose were observed in five cases. The strains overexpressing SOL3 and TAL1 grew 19% and 24% faster than their reference strain, and the strains carrying deletions of YLR042C, MNI1 or RPA49 grew 173%, 62% and 90% faster than their reference strain. Copyright (c) 2008 John Wiley & Sons, Ltd.

Status: Published Type: Journal Article PubMed ID: 19061191

Topics addressed in this paper

Number of different genes curated to this paper: 13

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
GAL1 GAL10 GAL2 GAL7 HIS3 HPM1 PUT4 RPA49 SOL3 TAL1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
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Genomic expression study yg ball
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Omics yg ball
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Topics Genes linked to topics (#11 - 13 )
YEF1 YLR042C YLR152C
Additional Literature blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Regulation of blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball
Strains/Constructs blue ball

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