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Hiraga S, et al.  (2008) Histone H3 lysine 56 acetylation by Rtt109 is crucial for chromosome positioning. J Cell Biol 183(4):641-51

Abstract: Correct intranuclear organization of chromosomes is crucial for many genome functions, but the mechanisms that position chromatin are not well understood. We used a layered screen to identify Saccharomyces cerevisiae mutants defective in telomere localization to the nuclear periphery. We find that events in S phase are crucial for correct telomere localization. In particular, the histone chaperone Asf1 functions in telomere peripheral positioning. Asf1 stimulates acetylation of histone H3 lysine 56 (H3K56) by the histone acetyltransferase Rtt109. Analysis of rtt109Delta and H3K56 mutants suggests that the acetylation/deacetylation cycle of the H3K56 residue is required for proper telomere localization. The function of H3K56 acetylation in localizing chromosome domains is not confined to telomeres because deletion of RTT109 also prevents the correct peripheral localization of a newly identified S. cerevisiae "chromosome-organizing clamp" locus. Because chromosome positioning is subject to epigenetic inheritance, H3K56 acetylation may mediate correct chromosome localization by facilitating accurate transmission of chromatin status during DNA replication.

Status: Published Type: Journal Article PubMed ID: 19001125

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Genes linked to topics (#1 - 10 )
ACE2 ASF1 AST1 BRE2 CHL1 CSM4 CTF18 CTF4 ELP3 ELP4
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Topics Genes linked to topics (#11 - 20 )
GBP2 HHT1 HHT2 IMD4 JJJ1 MRE11 PGD1 PHO23 RAD27 RAP1
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Topics Genes linked to topics (#21 - 30 )
RRM3 RRN3 RSC2 RTT109 SIC1 SIR3 SIR4 SPE1 SWI3 TDP1
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Topics Genes linked to topics (#31 - 34 )
TEL1 VPS75 YKU70 YKU80
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