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Woo DK, et al.  (2009) Multiple pathways of mitochondrial-nuclear communication in yeast: Intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation. Biochim Biophys Acta 1789(2):135-45

Abstract: Mitochondrial-nuclear communication is taking on increased importance in models of oxygen sensing, oxidative stress, aging, and disease. The deletion of the mitochondrial genome (mtDNA) and, hence, the ability to respire, affects expression of several nuclear genes through at least two different mitochondrial-nuclear communication pathways. One of the pathways, retrograde regulation, is activated by a reduction in respiration, while another, intergenomic signaling, is unaffected by respiration but requires mtDNA. Using DNA microarrays, we identify here a set of nuclear genes in Saccharomyces cerevisiae that are targets of intergenomic signaling. These nuclear genes are down-regulated in rho degrees cells that lack mtDNA but not in nuclear pet mutant rho(+)cells that possess mtDNA but lack respiration. Many of these nuclear genes encode mitochondrial proteins, implying that intergenomic signaling functions in coordinating mitochondrial and nuclear gene expression. In addition, analyses of deletion and linker scanning mutations in the promoter of the COX6 gene, a nuclear gene affected by intergenomic signaling, suggest an involvement of Abf1p transcription factor in intergenomic signaling. Together, these findings indicate that intergenomic signaling is distinct from retrograde regulation both in the nuclear genes that it regulates and in the way in which it affects their expression.

Status: Published Type: Journal Article PubMed ID: 18977319

Topics addressed in this paper

Number of different genes curated to this paper: 90

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ABF1 ACH1 AGX1 ALD3 ARG4 ARG7 ARO4 ATO2 ATO3 ATP14
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Genomic expression study yg ball
Omics yg ball
Regulatory Role blue ball
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Topics Genes linked to topics (#11 - 20 )
ATP16 ATP17 ATP19 ATP2 ATP20 ATP3 ATP4 ATP5 ATP7 BAT1
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Topics Genes linked to topics (#21 - 30 )
BNA1 BNA2 BNA4 CAT8 COR1 COX13 COX4 COX5A COX6 COX7
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DNA/RNA Sequence Features blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball
Regulation of blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
COX8 COX9 CPA2 CST9 CTT1 DIC1 FAT3 FCJ1 FIS1 FMP43
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Topics Genes linked to topics (#41 - 50 )
GPX2 GRE2 GUT1 HBT1 HIS3 IDP2 INH1 KGD1 KGD2 MEF2
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Topics Genes linked to topics (#51 - 60 )
MET13 MET17 MET3 MET6 MGM101 MIP6 MIR1 MSN2 NDI1 NDT80
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Regulatory Role blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
ODC1 ODC2 OPT2 PDH1 PDR15 PDR3 PDR5 PRM5 QCR2 QCR6
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Topics Genes linked to topics (#71 - 80 )
QCR7 RSB1 SAM3 SAM4 SDH1 SDH2 SDH3 SDH4 SNZ2 SOD2
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#81 - 90 )
SRY1 SUR7 TIM11 UME6 YIG1 YLR042C YLR294C YLR346C YMR102C YOR152C
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Regulatory Role blue ball
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