SGD Paper 
Bouck DC, et al. (2008) Design features of a mitotic spindle: balancing tension and compression at a single microtubule kinetochore interface in budding yeast. Annu Rev Genet 42:335-59
Abstract: Accurate segregation of duplicated chromosomes ensures that daughter cells get one and only one copy of each chromosome. Errors in chromosome segregation result in aneuploidy and have severe consequences on human health. Incorrect chromosome number and chromosomal instability are hallmarks of tumor cells. Hence, segregation errors are thought to be a major cause of tumorigenesis. A study of the physical mechanical basis of chromosome segregation is essential to understand the processes that can lead to errors. Tremendous progress has been made in recent years in identifying the proteins necessary for chromosome movement and segregation, but the mechanism and structure of critical force generating components and the molecular basis of centromere stiffness remain poorly understood. Expected final online publication date for the Annual Review of Genetics Volume 42 is November 3, 2008. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
| Status: Published | Type: Journal Article | PubMed ID: 18680435 |
Topics addressed in this paper
Number of different genes curated to this paper: 35
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| Topics | Genes linked to topics (#11 - 20 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CTF13 | CTF19 | DAM1 | ESP1 | IPL1 | IRR1 | KAR3 | KIP1 | MCD1 | MTW1 | |
| Reviews |  | | | | | | | | | |
| Topics | Genes linked to topics (#21 - 30 ) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| NUF2 | PDS1 | SGO1 | SGT1 | SKP1 | SLI15 | SLK19 | SMC1 | SMC2 | SMC3 | |
| Reviews | | | | | | | | | | |
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
