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Wu CY, et al.  (2008) Differential control of Zap1-regulated genes in response to zinc deficiency in Saccharomyces cerevisiae. BMC Genomics 9:370

Abstract: ABSTRACT: BACKGROUND: The Zap1 transcription factor is a central player in the response of yeast to changes in zinc status. We previously used transcriptome profiling with DNA microarrays to identify 46 potential Zap1 target genes in the yeast genome. In this new study, we used complementary methods to identify additional Zap1 target genes. RESULTS: With alternative growth conditions for the microarray experiments and a more sensitive motif identification algorithm, we identified 31 new potential targets of Zap1 activation. Moreover, an analysis of the response of Zap1 target genes to a range of zinc concentrations and to zinc withdrawal over time demonstrated that these genes respond differently to zinc deficiency. Some genes are induced under mild zinc deficiency and act as a first line of defense against this stress. First-line defense genes serve to maintain zinc homeostasis by increasing zinc uptake, and by mobilizing and conserving intracellular zinc pools. Other genes respond only to severe zinc limitation and act as a second line of defense. These second-line defense genes allow cells to adapt to conditions of zinc deficiency and include genes involved in maintaining secretory pathway and cell wall function, and stress responses. CONCLUSIONS: We have identified several new targets of Zap1-mediated regulation. Furthermore, our results indicate that through the differential regulation of its target genes, Zap1 prioritizes mechanisms of zinc homeostasis and adaptive responses to zinc deficiency.

Status: Published Type: Journal Article PubMed ID: 18673560

Topics addressed in this paper

Number of different genes curated to this paper: 61

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADE17 ADH4 ALD2 ALD3 ATG19 BAG7 COS1 COS6 CTT1 DPP1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
ENO1 ENO2 FET4 FMP43 GPG1 HNT1 HPF1 HSP12 HSP26 ICY2
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
IZH1 IZH2 LAP3 MCD4 MNT2 MOH1 PEP4 PET10 PET20 PHM7
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Topics Genes linked to topics (#31 - 40 )
PIG2 PIR3 PRB1 PRC1 PST1 PUT4 SAM3 SCW4 SED1 TDH1
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Topics Genes linked to topics (#41 - 50 )
TIS11 TKL2 TSA1 UBX6 URA10 UTH1 VEL1 YBL029W YBR285W YHR214W-A
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Topics Genes linked to topics (#51 - 60 )
YJL132W YMR181C YNR066C YOR387C ZAP1 ZPS1 ZRC1 ZRG17 ZRT1 ZRT2
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Mutants/Phenotypes blue ball
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Protein-Nucleic Acid Interactions blue ball
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Regulatory Role blue ball
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Topics Genes linked to topics (#61 )
ZRT3
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