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Malagon F and Jensen TH  (2008) The T body, a new cytoplasmic RNA granule in Saccharomyces cerevisiae. Mol Cell Biol 28(19):6022-32

Abstract: A large share of mRNA processing and packaging events occurs co-transcriptionally. To explore the hypothesis that transcription defects may affect mRNA fate, we analyzed poly(A)(+) RNA distribution in Saccharomyces cerevisiae strains harboring mutations in Rpb1p, the largest subunit of RNA polymerase II. In certain rpb1 mutants, a poly(A)(+) RNA granule, distinct from any known structure, strongly accumulated in a confined space of the cytoplasm. RNA and protein expressed from Ty1 retroviral-like elements co-localized with this new granule, that we have consequently named the T-body. A visual screen revealed that deletion of most genes with proposed functions in Ty1 biology unexpectedly do not alter T-body levels. In contrast, deletion of genes encoding the Mediator transcription initiation factor subunits Srb2p and Srb5p as well as the Ty1 transcriptional regulator Spt21p, greatly enhance T-body formation. Our data disclose a new cellular body putatively involved in assembly of Ty1 particles, and suggest that the cytoplasmic fate of mRNA can be affected by transcription initiation events.

Status: Published Type: Journal Article PubMed ID: 18678648

Topics addressed in this paper

Number of different genes curated to this paper: 79

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Topics Genes linked to topics (#1 - 10 )
ASF1 BAS1 BYE1 CHD1 CSE2 DBR1 DST1 ELF1 ELG1 FUS3
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Topics Genes linked to topics (#11 - 20 )
HIR2 HTA1 LEO1 MBP1 MED1 MMS1 PAP1 PGD1 RAD51 RAD52
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Topics Genes linked to topics (#21 - 30 )
RPB4 RPB9 RPO21 RRM3 RTF1 RTT101 RTT103 RTT106 RTT107 RTT109
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Topics Genes linked to topics (#31 - 40 )
SIN4 SNF2 SOH1 SPT10 SPT2 SPT21 SPT3 SPT4 SPT8 SRB2
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Topics Genes linked to topics (#41 - 50 )
SRB5 SSN2 SSN3 SSN8 SWI4 SWI6 TAF14 TEC1 YARCTy1-1 YBLWTy1-1
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Topics Genes linked to topics (#51 - 60 )
YBRWTy1-2 YDRCTy1-1 YDRCTy1-2 YDRCTy1-3 YDRWTy1-4 YDRWTy1-5 YERCTy1-1 YERCTy1-2 YGRCTy1-2 YGRCTy1-3
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Topics Genes linked to topics (#61 - 70 )
YGRWTy1-1 YHRCTy1-1 YJRWTy1-1 YJRWTy1-2 YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YMLWTy1-1 YMLWTy1-2 YMRCTy1-3
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Topics Genes linked to topics (#71 - 79 )
YMRCTy1-4 YNLCTy1-1 YNLWTy1-2 YOLWTy1-1 YORWTy1-2 YPLWTy1-1 YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
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