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Melamed D, et al.  (2008) Yeast translational response to high salinity: global analysis reveals regulation at multiple levels. RNA 14(7):1337-51

Abstract: Genome-wide studies of steady-state mRNA levels revealed common principles underlying transcriptional changes in response to external stimuli. To uncover principles that govern other stages of the gene-expression response, we analyzed the translational response and its coordination with transcriptome changes following exposure to severe stress. Yeast cells were grown for 1 h in medium containing 1 M NaCl, which elicits a maximal but transient translation inhibition, and nonpolysomal or polysomal mRNA pools were subjected to DNA-microarray analyses. We observed a strong repression in polysomal association for most mRNAs, with no simple correlation with the changes in transcript levels. This led to an apparent accumulation of many mRNAs as a nontranslating pool, presumably waiting for recovery from the stress. However, some mRNAs demonstrated a correlated change in their polysomal association and their transcript levels (i.e., potentiation). This group was enriched with targets of the transcription factors Msn2/Msn4, and the translational induction of several tested mRNAs was diminished in an Msn2/Msn4 deletion strain. Genome-wide analysis of a strain lacking the high salinity response kinase Hog1p revealed that the group of translationally affected genes is significantly enriched with motifs that were shown to be associated with the ARE-binding protein Pub1. Since a relatively small number of genes was affected by Hog1p deletion, additional signaling pathways are likely to be involved in coordinating the translational response to severe salinity stress.

Status: Published Type: Journal Article PubMed ID: 18495938

Topics addressed in this paper

Number of different genes curated to this paper: 87

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADK1 AIM17 ALD3 AQR1 ARG2 ARG3 ARG5,6 ARG7 ARG80 ARG81
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Topics Genes linked to topics (#11 - 20 )
ARG82 AST1 BCY1 BTN2 CAR1 CBK1 CCW14 CHS7 CUP1-2 CWP2
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Topics Genes linked to topics (#21 - 30 )
CYS4 DBF2 DDR2 ERG6 FES1 FMP41 FMP43 GCN4 GPD1 GRX2
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Topics Genes linked to topics (#31 - 40 )
GUK1 HMT1 HOG1 HOR2 HSP104 HSP12 HSP42 IMD4 KRE1 LYP1
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Topics Genes linked to topics (#41 - 50 )
MAS1 MBF1 MIR1 MSC1 MSN2 MSN4 NCE103 NCL1 ORM2 PDR15
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Topics Genes linked to topics (#51 - 60 )
PDR5 PHO84 PIR1 PMC1 PMP1 PSA1 PST2 RHR2 RNR2 RPL32
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Topics Genes linked to topics (#61 - 70 )
RPS22A SBE22 SEC61 SED1 SIS2 SLT2 SNA3 SOD1 SPI1 SSA4
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Topics Genes linked to topics (#71 - 80 )
STL1 TDH2 TIP41 TRX1 TSA1 URA5 VMA13 VMA3 VMA4 VMA6
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Topics Genes linked to topics (#81 - 87 )
YDL023C YDL124W YGR035C YHB1 YHR033W YPT1 ZUO1
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