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Steffen KK, et al.  (2008) Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. Cell 133(2):292-302

Abstract: In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular processes including stress responses, protein turnover, cell growth, and ribosome biogenesis. Here we show that a specific reduction of 60S ribosomal subunit levels slows aging in yeast. Deletion of genes encoding 60S subunit proteins or processing factors or treatment with a small molecule, which all inhibit 60S subunit biogenesis, are each sufficient to significantly increase replicative life span. One mechanism by which reduced 60S subunit levels leads to life span extension is through induction of Gcn4, a nutrient-responsive transcription factor. Genetic epistasis analyses suggest that dietary restriction, reduced 60S subunit abundance, and Gcn4 activation extend yeast life span by similar mechanisms.

Status: Published Type: Journal Article | Research Support, N.I.H., Extramural | Research Support, Non-U.S. Gov't PubMed ID: 18423200

Topics addressed in this paper

Number of different genes curated to this paper: 117

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Topics Genes linked to topics (#1 - 10 )
FOB1 GCN2 GCN4 LOC1 NOP12 REI1 RPL11B RPL12A RPL12B RPL13A
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
RPL13B RPL14A RPL15B RPL16A RPL16B RPL17B RPL18B RPL19A RPL19B RPL1A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
RPL1B RPL20A RPL20B RPL21A RPL21B RPL22A RPL22B RPL23A RPL23B RPL24A
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
RPL24B RPL26A RPL26B RPL27B RPL29 RPL2A RPL2B RPL31A RPL31B RPL33B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
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Topics Genes linked to topics (#41 - 50 )
RPL34A RPL34B RPL35A RPL35B RPL36A RPL37A RPL37B RPL38 RPL39 RPL40A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#51 - 60 )
RPL40B RPL41A RPL41B RPL43A RPL43B RPL4A RPL6A RPL6B RPL7A RPL7B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
RPL8A RPL8B RPL9A RPL9B RPP1A RPP1B RPP2A RPP2B RPS0A RPS0B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#71 - 80 )
RPS10A RPS10B RPS11A RPS11B RPS14A RPS14B RPS16A RPS16B RPS17A RPS17B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#81 - 90 )
RPS18A RPS18B RPS19A RPS19B RPS1A RPS1B RPS21A RPS21B RPS22A RPS22B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.

Topics Genes linked to topics (#91 - 100 )
RPS23A RPS23B RPS24A RPS24B RPS25A RPS25B RPS26B RPS27A RPS27B RPS28A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#101 - 110 )
RPS28B RPS29A RPS30A RPS30B RPS4A RPS4B RPS6A RPS6B RPS7A RPS7B
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#111 - 117 )
RPS8A RPS9A RPS9B SCH9 SIR2 SSF1 TOR1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Cell Growth and Metabolism blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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