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Abe F and Minegishi H  (2008) Global screening of genes essential for growth in high-pressure and cold environments: searching for basic adaptive strategies using a yeast deletion library. Genetics 178(2):851-72

Abstract: Microorganisms display an optimal temperature and hydrostatic pressure for growth. To establish the molecular basis of piezo- and psychro-adaptation, we elucidated global genetic defects that give rise to susceptibility to high pressure and low temperature in Saccharomyces cerevisiae. Here we present 80 genes including 71 genes responsible for high-pressure growth and 56 responsible for low-temperature growth with a significant overlap of 47 genes. Numerous previously known cold-sensitive mutants exhibit marked high-pressure sensitivity. We identified critically important cellular functions: (i) amino acid biosynthesis; (ii) microautophagy and sorting of amino acid permease established by the EGO/GSE complex; (iii) mitochondrial functions; (iv) membrane trafficking; (v) actin organization mediated by Drs2-Cdc50; and (vi) transcription regulated by the Ccr4-Not complex. The loss of EGO/GSE complex resulted in a marked defect in amino acid uptake following high-pressure and low-temperature incubation, suggesting its role in surface delivery of amino acid permeases. Microautophagy and mitochondrial functions converge on glutamine homeostasis in the TOR signaling pathway. The localization of actin requires numerous associated proteins to be properly delivered in by membrane trafficking. In this study, we offer a novel route to gaining insights into cellular functions and the genetic network from growth properties of deletion mutants under high pressure and low temperature.

Status: Published Type: Journal Article PubMed ID: 18245339

Topics addressed in this paper

Number of different genes curated to this paper: 121

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACO1 AGP1 AGP2 AGP3 AKR1 ALP1 ARD1 ARG82 ARO1 ARO2
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Topics Genes linked to topics (#11 - 20 )
ATP15 AVL9 BAP2 BAP3 BIO5 CAN1 CCR4 CDC50 CDC73 CGI121
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Topics Genes linked to topics (#21 - 30 )
CHC1 CLA4 CSF1 DIP5 DLT1 DRS2 ELF1 ERG24 GAP1 GNP1
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Topics Genes linked to topics (#31 - 40 )
GTR1 GTR2 HFI1 HIP1 HNM1 HOF1 HOM3 HSP31 HXT1 HXT10
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Topics Genes linked to topics (#41 - 50 )
HXT11 HXT13 HXT14 HXT15 HXT16 HXT17 HXT2 HXT3 HXT4 HXT5
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Topics Genes linked to topics (#51 - 60 )
HXT6 HXT7 HXT8 HXT9 IBA57 IES2 KCS1 LEU3 LTE1 LYP1
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Topics Genes linked to topics (#61 - 70 )
MDJ1 MEH1 MMP1 MOT2 MRF1 MRP51 MRPL22 MRPL38 MSY1 MTC2
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Topics Genes linked to topics (#71 - 80 )
MTC4 MTC6 MUP1 MUP3 NBP2 PAF1 PAR32 PEP3 PEP5 PHO88
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Topics Genes linked to topics (#81 - 90 )
PLC1 POP2 PUT4 RPB4 RPL1B RPL21A RPS30B SAC1 SAM1 SAP155
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Topics Genes linked to topics (#91 - 100 )
SEC22 SER1 SHE3 SLM3 SLM4 SLM6 SNF1 SNF6 SRB5 SSY1
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Topics Genes linked to topics (#101 - 110 )
TAF14 TAT1 TAT2 THR4 TPO5 TRP1 TRP2 TRP4 TRP5 UGA4
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Topics Genes linked to topics (#111 - 120 )
VID24 VPS34 VPS45 VPS54 YAF9 YDJ1 YDL172C YDR008C YDR442W YGL218W
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Topics Genes linked to topics (#121 )
YPR153W
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