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Schluter C, et al.  (2008) Global Analysis of Yeast Endosomal Transport Identifies the Vps55/68 Sorting Complex. Mol Biol Cell 19(4):1282-1294

Abstract: Monitoring Editor: Sandra Lemmon Endosomal transport is critical for cellular processes ranging from receptor down-regulation and retroviral budding to the immune response. A full understanding of endosome sorting requires a comprehensive picture of the multiprotein complexes that orchestrate vesicle formation and fusion. Here, we use unsupervised, large-scale phenotypic analysis and a novel computational approach for the global identification of endosomal transport factors. This technique effectively identifies components of known and novel protein assemblies. We report the characterization of a previously undescribed endosome sorting complex that contains two well-conserved proteins with 4 predicted membrane-spanning domains. Vps55p and Vps68p form a complex that acts with or downstream of ESCRT function to regulate endosomal trafficking. Loss of Vps68p disrupts recycling to the TGN as well as onward trafficking to the vacuole without preventing the formation of lumenal vesicles within the MVB. Our results suggest the Vps55/68 complex mediates a novel, conserved step in the endosomal maturation process.

Status: Published Type: Journal Article PubMed ID: 18216282

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Number of different genes curated to this paper: 96

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AKR1 ARF1 ARP5 ARP6 BRO1 BUD32 CDC50 COG5 COG6 COG7
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COG8 DID4 EAF1 HPR1 HTZ1 HUR1 IES6 NBP2 NEM1 NHX1
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Topics Genes linked to topics (#21 - 30 )
NPL6 PEP1 PEP7 PEP8 PFD1 PMR1 RGP1 RIC1 RSC2 SAM37
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Topics Genes linked to topics (#31 - 40 )
SNF1 SNF7 SNF8 SPO7 SRN2 STE3 STP22 SWC3 SWC5 SWR1
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Topics Genes linked to topics (#41 - 50 )
THP1 VAM10 VAM3 VAM7 VMA1 VMA10 VMA11 VMA13 VMA16 VMA2
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Topics Genes linked to topics (#51 - 60 )
VMA21 VMA22 VMA3 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1 VPH2
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Topics Genes linked to topics (#61 - 70 )
VPS13 VPS15 VPS17 VPS20 VPS21 VPS24 VPS25 VPS27 VPS28 VPS29
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Topics Genes linked to topics (#71 - 80 )
VPS3 VPS30 VPS34 VPS35 VPS36 VPS38 VPS4 VPS41 VPS5 VPS51
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Topics Genes linked to topics (#81 - 90 )
VPS52 VPS54 VPS55 VPS63 VPS68 VPS69 VPS71 VPS72 VPS8 VPS9
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Topics Genes linked to topics (#91 - 96 )
YCL007C YDR455C YKL118W YLR358C YOR331C YPT6
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