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Fong CS, et al.  (2008) Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor. FEMS Yeast Res 8(3):386-99

Abstract: Cells treated with low doses of linoleic acid hydroperoxide (LoaOOH) exhibit a cell-cycle delay that may provide a mechanism to overcome oxidative stress. Strains sensitive to LoaOOH from the genome-wide deletion collection were screened to identify deletants in which the cell-cycle delay phenotype was reduced. Forty-seven deletants were identified that were unable to mount the normal delay response, implicating the product of the deleted gene in the oxidant-mediated cell-cycle delay of the wild-type. Of these genes, SWI6 was of particular interest due to its role in cell-cycle progression through Start. The swi6 deletant strain was delayed on entry into the cell cycle in the absence of an oxidant, and oxidant addition caused no further delay. Transforming the swi6 deletant with SWI6 on a plasmid restored the G1 arrest in response to LoaOOH, indicating that Swi6p is involved in oxidant sensing leading to cell division delay. Micro-array studies identified genes whose expression in response to LoaOOH depended on SWI6. The screening identified 77 genes that were upregulated in the wild-type strain and concurrently downregulated in the swi6 deletant treated with LoaOOH. These data show that functions such as heat shock response, and glucose transport are involved in the response.

Status: Published Type: Journal Article PubMed ID: 18205808

Topics addressed in this paper

Number of different genes curated to this paper: 87

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADE12 ADE13 ADE17 ADE4 ADE5,7 ALD3 ASF1 BMH1 BTN2 CAX4
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball
Genomic expression study yg ball
Large-scale phenotype analysis yg ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Omics yg ball
Primary Literature blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
COX15 CPR6 CWP1 EOS1 FIS1 GAL11 GIN4 GTR2 GTT2 HBT1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 30 )
HCR1 HIS4 HMO1 HSP104 HSP26 HSP30 HSP42 HSP78 HSP82 HXT2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball
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RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
HXT6 HXT7 IRC14 IWR1 MAP1 MED2 MMS22 MRT4 MSH6 MTD1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#41 - 50 )
OCA1 OCA4 OPI3 OYE2 PAR32 PDX3 PEP3 PEX19 PFK26 PGD1
Additional Literature blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball
Regulatory Role blue ball
RNA Levels and Processing blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#51 - 60 )
POM33 PTC1 ROX3 RPE1 RTC3 RTT109 SHM2 SIS1 SIW14 SNF5
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball
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Strains/Constructs blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#61 - 70 )
SNF6 SNQ2 SRB5 SRB6 SSA3 SSA4 STI1 SUR1 SWI3 SWI6
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Genetic Interactions blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#71 - 80 )
TAT1 THI7 THR4 TIF3 TKL1 TMA10 TOF1 VMA4 YAP1 YBR285W
Additional Literature blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball
Regulatory Role blue ball
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Topics Genes linked to topics (#81 - 87 )
YCR061W YGR064W YHR138C YIL077C YLL056C YLR456W ZTA1
Additional Literature blue ball blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Regulation of blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball
Strains/Constructs blue ball blue ball blue ball blue ball
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