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Nyswaner KM, et al.  (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214

Abstract: Chromosomal genes modulate Ty retrotransposon movement in the genome of Saccharomyces cerevisiae. We have screened a collection of 4739 deletion mutants to identify those that increase Ty1 mobility (Ty1 restriction genes). Among the 91 identified mutants, 80% encode products involved in nuclear processes such as chromatin structure and function, DNA repair and recombination, and transcription. However, bioinformatic analyses encompassing additional Ty1 and Ty3 screens indicate that 264 unique genes involved in a variety of biological processes affect Ty mobility in yeast. Further characterization of 33 of the mutants identified here show that Ty1 RNA levels increase in 5 mutants and the rest affect mobility post-transcriptionally. RNA and cDNA levels remain unchanged in mutants defective in transcription elongation, including ckb2Delta and elf1Delta, suggesting that Ty1 integration may be more efficient in these strains. Insertion-site preference at the CAN1 locus requires Ty1 restriction genes involved in histone H2B ubiquitination by Paf complex subunit genes, as well as BRE1 and RAD6, histone H3 acetylation by RTT109 and ASF1, and transcription elongation by SPT5. Our results indicate that multiple pathways restrict Ty1 mobility and histone modifications may protect coding regions from insertional mutagenesis.

Status: Published Type: Journal Article PubMed ID: 18202368

Topics addressed in this paper

Number of different genes curated to this paper: 138

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AGP2 AGP3 ALR2 ARC1 ARG4 ARG82 ASC1 ASF1 BEM4 BRE1
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Topics Genes linked to topics (#11 - 20 )
BUD27 CAN1 CDC40 CDC73 CKB2 CLD1 CLN2 CSE2 DIG1 EAF3
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Topics Genes linked to topics (#21 - 30 )
ELF1 ELG1 ERT1 ESC1 ESC2 GCR2 GDS1 HFD1 HHT1 HIR2
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Topics Genes linked to topics (#31 - 40 )
HIR3 HOG1 HPC2 IPK1 IRC24 KCS1 LEO1 MDM34 MMS1 MMS22
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Topics Genes linked to topics (#41 - 50 )
MRE11 MSN4 NFI1 NRM1 NYV1 PAF1 PBS2 PDE2 PHD1 PPZ1
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Topics Genes linked to topics (#51 - 60 )
RAD18 RAD27 RAD50 RAD51 RAD52 RAD54 RAD55 RAD57 RAD6 RDS1
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Topics Genes linked to topics (#61 - 70 )
RNR4 RPA14 RPD3 RRM3 RTF1 RTT10 RTT101 RTT106 RTT107 RTT109
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Topics Genes linked to topics (#71 - 80 )
SAE2 SAE3 SGF29 SGS1 SIC1 SIN3 SOH1 SPT21 SPT5 SRB5
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Topics Genes linked to topics (#81 - 90 )
SSK2 SSK22 STB5 TRM7 VPS64 XDJ1 YBLWTy1-1 YBLWTy2-1 YBRWTy1-2 YCLWTy2-1
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Topics Genes linked to topics (#91 - 100 )
YCR087C-A YDRCTy1-1 YDRCTy1-2 YDRCTy2-1 YDRWTy1-4 YDRWTy1-5 YDRWTy2-2 YDRWTy2-3 YEL008W YERCTy1-1
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Topics Genes linked to topics (#101 - 110 )
YERCTy1-2 YFLWTy2-1 YGRCTy1-2 YGRCTy1-3 YGRWTy1-1 YGRWTy2-2 YGRWTy3-1 YHLWTy4-1 YHRCTy1-1 YILWTy3-1
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Topics Genes linked to topics (#111 - 120 )
YJLWTy4-1 YJR142W YJRWTy1-1 YJRWTy1-2 YLR282C YLRCTy1-1 YLRWTy1-2 YLRWTy1-3 YLRWTy2-1 YML009W-B
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Topics Genes linked to topics (#121 - 130 )
YMLWTy1-1 YMLWTy1-2 YMR221C YMR226C YMRCTy1-3 YMRCTy1-4 YNLCTy1-1 YNLWTy1-2 YNR073C YOLWTy1-1
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Topics Genes linked to topics (#131 - 138 )
YORCTy2-1 YORWTy1-2 YORWTy2-2 YPLCTy4-1 YPLWTy1-1 YPRCTy1-2 YPRCTy1-4 YPRWTy1-3
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