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Alvaro D, et al.  (2007) Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. PLoS Genet 3(12):e228

Abstract: To investigate the DNA damage response, we undertook a genome-wide study in Saccharomyces cerevisiae and identified 86 gene deletions that lead to increased levels of spontaneous Rad52 foci in proliferating diploid cells. More than half of the genes are conserved across species ranging from yeast to humans. Along with genes involved in DNA replication, repair, and chromatin remodeling, we found 22 previously uncharacterized open reading frames. Analysis of recombination rates and synthetic genetic interactions with rad52Delta suggests that multiple mechanisms are responsible for elevated levels of spontaneous Rad52 foci, including increased production of recombinogenic lesions, sister chromatid recombination defects, and improper focus assembly/disassembly. Our cell biological approach demonstrates the diversity of processes that converge on homologous recombination, protect against spontaneous DNA damage, and facilitate efficient repair.

Status: Published Type: Journal Article PubMed ID: 18085829

Topics addressed in this paper

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AHC1 ATR1 BCK1 BDF1 BDF2 BUB2 BUD27 CBT1 COX16 CTF19
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Topics Genes linked to topics (#11 - 20 )
CTF4 DAK2 DDC1 DDR2 ECM11 ELG1 ESC2 GDH1 GSH2 HPR1
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Topics Genes linked to topics (#21 - 30 )
HST3 IRC10 IRC11 IRC13 IRC14 IRC15 IRC16 IRC18 IRC19 IRC2
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Topics Genes linked to topics (#31 - 40 )
IRC20 IRC21 IRC22 IRC23 IRC24 IRC25 IRC3 IRC4 IRC5 IRC6
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Topics Genes linked to topics (#41 - 50 )
IRC7 IRC8 IRC9 IZH2 LAG2 LCB5 LRS4 MAD1 MAD2 MDM20
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Topics Genes linked to topics (#51 - 60 )
MED1 MLH1 MMS1 MRP17 MRPL1 MRPS16 MUS81 NUP133 NUP60 PAC10
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Topics Genes linked to topics (#61 - 70 )
PAP2 PDR10 POM152 RAD51 RAD52 RAD54 RAD57 RAD59 RCO1 RIM9
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Topics Genes linked to topics (#71 - 80 )
RMI1 RRM3 RTT101 RTT103 RTT107 RTT109 SAE2 SGO1 SGS1 SLX8
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Topics Genes linked to topics (#81 - 89 )
TOF2 VPS71 VPS72 WSS1 YDL071C YDR290W YMR027W YMR31 YOR024W
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