Fiechter V, et al. (2008) The evolutionary conserved BER1 gene is involved in microtubule stability in yeast. Curr Genet 53(2):107-15
Abstract: In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and circadian rhythms in Arabidopsis. Here, we present data showing that the ber1Delta mutant is affected in microtubule stability, particularly in presence of microtubule-depolymerising drugs. The pattern of synthetic lethal interactions obtained with the ber1Delta mutant suggests that Ber1 may function in N-terminal protein acetylation. Our work thus suggests that microtubule stability might be regulated through this post-translational modification on yet-to-be determined proteins.
|Status: Published||Type: Journal Article||PubMed ID: 18064466|
Topics addressed in this paper
Number of different genes curated to this paper: 21
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|Topics||Topics not linked to Genes||Genes linked to topics (#1 - 10 )|
|Large-scale genetic interaction|
|Non-Fungal Related Genes/Proteins|
|Topics||Genes linked to topics (#11 - 20 )|
|Topics||Genes linked to topics (#21 )|