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Fiechter V, et al.  (2008) The evolutionary conserved BER1 gene is involved in microtubule stability in yeast. Curr Genet 53(2):107-15

Abstract: In yeast, microtubules are dynamic filaments necessary for spindle and nucleus positioning, as well as for proper chromosome segregation. We identify a function for the yeast gene BER1 (Benomyl REsistant 1) in microtubule stability. BER1 belongs to an evolutionary conserved gene family whose founding member Sensitivity to Red light Reduced is involved in red-light perception and circadian rhythms in Arabidopsis. Here, we present data showing that the ber1Delta mutant is affected in microtubule stability, particularly in presence of microtubule-depolymerising drugs. The pattern of synthetic lethal interactions obtained with the ber1Delta mutant suggests that Ber1 may function in N-terminal protein acetylation. Our work thus suggests that microtubule stability might be regulated through this post-translational modification on yet-to-be determined proteins.

Status: Published Type: Journal Article PubMed ID: 18064466

Topics addressed in this paper

Number of different genes curated to this paper: 21

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AMD1 ARD1 BER1 BUB1 BUB3 CIN8 CSE4 CTK2 CTK3 HAL5
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Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Large-scale genetic interaction yg ball
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Non-Fungal Related Genes/Proteins yg ball
Omics yg ball
Primary Literature blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
HNT3 IPL1 NAT1 NKP2 NNF1 RPN4 RVS161 SHP1 SLX8 YDR444W
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 )
YER068C-A
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Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Strains/Constructs blue ball

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