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Sirisattha S, et al.  (2004) Toxicity of anionic detergents determined by Saccharomyces cerevisiae microarray analysis. Water Res 38(1):61-70

Abstract: Sodium n-dodecyl benzene sulfonate (LAS) and sodium dodecyl sulfate (SDS) are popular anionic detergents (surfactants) that are used worldwide and the toxicities of these chemicals have been characterized. We applied these chemicals in a DNA microarray bioassay and determined that the microarray data reflects previous findings and also provides some new information about anionic detergent toxicity. The mRNA expression profiles suggest that LAS and SDS cause damage to membranes and alterations in carbon metabolism, and induce the oxidative stress response. We also found that LAS and SDS induce the pleiotropic drug-resistance network, and that LAS and SDS may be pumped out of yeast cells by this network. Hierarchical clustering of the expression profiles showed that LAS and SDS cause similar features of toxicity and that the toxicity is similar to that of capsaicin but different from that of cadmium and mercury.

Status: Published Type: Journal Article PubMed ID: 14630103

Topics addressed in this paper

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ATX1 CMK2 CRS5 DIA1 GPX1 GRE2 GRX1 GRX2 GRX6 GTT2
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GYP8 HSP12 HSP26 HYR1 IMP2 MAC1 MET30 PAM18 PDR15 PDR16
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Topics Genes linked to topics (#21 - 30 )
PDR5 PHR1 POX1 PRX1 RTA1 TMA10 TRX1 TRX2 WSC4 YHR054C
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Topics Genes linked to topics (#31 - 39 )
YHR138C YHR140W YLR046C YLR346C YNL211C YOR1 YOR385W YPL088W YSR3
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