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Menon AK (2007) A flip-flop switch in polarity signaling. Dev Cell 13(5):607-8
Abstract: The Rho GTPase Cdc42 is essential for polarized growth of budding yeast. Temporal control of Cdc42 depends partly on the activity of its GTPase-activating proteins (GAPs). In this issue of Developmental Cell, Saito et al. report that Cdc42 GAP activity is regulated by the phospholipid composition of the bud-tip membrane, under control of the phospholipid flippases Lem3-Dnf1 and Lem3-Dnf2.
| Status: Published | Type: Comment | PubMed ID: 17981130 |
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