Tachibana C, et al. (2007) A poised initiation complex is activated by SNF1. J Biol Chem 282(52):37308-15
Abstract: Snf1, the yeast AMP kinase homolog, is essential for derepression of glucose-repressed genes that are activated by Adr1. Although required for Adr1 DNA-binding, the precise role of Snf1 is unknown. Deletion of histone deacetylase genes allowed constitutive promoter binding of Adr1 and Cat8, another activator of glucose-repressed genes. In repressed conditions, at the Adr1-, and Cat8-dependent ADH2 promoter, partial chromatin remodeling had occurred and the activators recruited a partial pre-initiation complex that included RNA Pol II. Transcription did not occur, however, unless Snf1 was activated, suggesting a Snf1-dependent event that occurs after RNA Pol II recruitment. Glucose regulation persisted because shifting to low glucose increased expression. Glucose repression could be completely relieved by combining the three elements of 1) chromatin perturbation by mutation of histone deacetylases, 2) activation of Snf1 and 3) addition of an Adr1 mutant that by itself confers only weak constitutive activity.
|Status: Published||Type: Journal Article||PubMed ID: 17974563|
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