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Yousef AF, et al.  (2008) Coactivator requirements for p53-dependent transcription in the yeast Saccharomyces cerevisiae. Int J Cancer 122(4):942-6

Abstract: p53 is a sequence-specific DNA-binding transcription factor and key regulator of cell cycle arrest and apoptosis. p53 is mutated in most human cancers and these mutations generally impair its ability to activate transcription. When expressed in Saccharomyces cerevisiae, p53 acts as a strong transcriptional activator allowing yeast to be used as a model system to study the effects of p53 mutations on activity. However, little is known about the exact mechanisms by which p53 functions in yeast. Using 76 mutant yeast strains, we have evaluated the effect of deleting components of the ADA, COMPASS, INO80, ISW1, Mediator, RSC, SAGA, SAS, SLIK, SWI/SNF, and SWR1 transcriptional regulatory complexes on p53-dependent transcription. In addition, we examined the role of histone H2B ubiquitylation by Rad6/Bre1 on p53 activation. Overall, our analysis indicates that there are several remarkable similarities between p53-dependent transcription in yeast and mammalian cells, suggesting that yeast can serve as a valid model system for at least some aspects of p53 function. (c) 2007 Wiley-Liss, Inc.

Status: Published Type: Journal Article PubMed ID: 17957787

Topics addressed in this paper

Number of different genes curated to this paper: 46

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Topics Genes linked to topics (#1 - 10 )
ADA2 AHC1 BRE1 BRE2 CSE2 DOT1 GAL11 GCN5 HFI1 IOC2
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Topics Genes linked to topics (#11 - 20 )
IOC3 IOC4 ISW1 MED1 NGG1 RAD18 RAD6 ROX3 RTG2 SAS5
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Topics Genes linked to topics (#21 - 30 )
SDC1 SGF11 SGF73 SHG1 SIN4 SNF11 SNF12 SNF2 SNF5 SNF6
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Topics Genes linked to topics (#31 - 40 )
SPP1 SPT20 SPT3 SPT4 SPT7 SPT8 SRB5 SWD1 SWD3 SWI1
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Topics Genes linked to topics (#41 - 46 )
SWI3 TAF14 UBC5 UBP8 UBR2 YAF9
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