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De Nicola R, et al.  (2007) Physiological and Transcriptional Responses of Saccharomyces cerevisiae to Zinc Limitation in Chemostat Cultures. Appl Environ Microbiol 73(23):7680-92

Abstract: Transcriptional responses of Saccharomyces cerevisiae to Zn availability were investigated at a fixed specific growth rate under limiting and abundant Zn concentrations in chemostat culture. To investigate the context-dependency of this transcriptional response and eliminate growth rate-dependent variations in transcription, yeast was grown under several chemostat regimes resulting in various carbon (glucose), nitrogen (ammonium), zinc and oxygen supplies. A robust set of genes that responded consistently to Zn limitation was identified and enabled the definition of the Zn-specific Zap1 regulon comprising of 26 genes and characterized by a broader ZRE consensus (MHHAACCBYNMRGGT) than so far described. Most surprising was the Zn-dependent regulation of genes involved in storage carbohydrate metabolism. Their concerted down-regulation was physiologically relevant as revealed by a substantial decrease in glycogen and trehalose cellular content under Zn limitation. An unexpectedly large amount of genes were synergistically or antagonistically regulated by oxygen and Zn availability. This combinatorial regulation suggested a more prominent involvement of Zn in mitochondrial biogenesis and function than hitherto identified.

Status: Published Type: Journal Article PubMed ID: 17933919

Topics addressed in this paper

Number of different genes curated to this paper: 64

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADE17 ADH4 ATP14 ATP15 ATP18 ATP20 ATP3 ATP4 COX14 COX23
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Cell Growth and Metabolism yg ball
Genomic expression study yg ball
Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
DPP1 FET4 FLO11 GAC1 GDB1 GLC3 GPG1 GPH1 GSY2 HOR2
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Topics Genes linked to topics (#21 - 30 )
ICY2 IZH1 IZH2 KTI12 KTR6 MAM33 MBA1 MCD4 MET31 MET32
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Topics Genes linked to topics (#31 - 40 )
MNP1 MNT2 MRPL10 MRPL11 MRPL37 MRPS16 MSS116 MUP1 NRG2 PGM1
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Topics Genes linked to topics (#41 - 50 )
PGM2 PST1 RSM19 RTC4 SOD1 SOD2 TEX1 TIM10 TPS1 TPS2
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Topics Genes linked to topics (#51 - 60 )
TPS3 URA10 VEL1 VTC3 YER130C YOR387C ZAP1 ZIP1 ZPS1 ZRC1
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Topics Genes linked to topics (#61 - 64 )
ZRG17 ZRT1 ZRT2 ZRT3
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