Berger AB, et al. (2007) Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription. Mol Cell Biol 27(22):8015-26
Abstract: Ribosome biogenesis requires an equimolar amount of four rRNAs and each of the 79 ribosomal proteins (RP). Coordinated regulation of rRNA and RP synthesis by eukaryotic RNA polymerases (Pol) I, III and II is a key requirement for growth control. Using a novel global genetic approach, we could show that the absence of Hmo1 becomes lethal when combined with mutations of components of either the RNA Pol II or Pol I transcription machineries, of specific ribosomal proteins, or of the TOR pathway. Hmo1 directly interacts with both the region transcribed by Pol I and with a subset of RP gene promoters. Down regulation of Hmo1 expression affects RP gene expression. Upon TORC1 inhibition, Hmo1 dissociates from rDNA and some RP gene promoters simultaneously. Finally, in the absence of Hmo1, TOR dependent repression of RP genes is alleviated. Therefore, we show here that S. cerevisiae Hmo1 is directly involved in coordinating rDNA transcription by Pol I and RP gene expression by Pol II, under the control of the TOR pathway.
|Status: Published||Type: Journal Article||PubMed ID: 17875934|
Topics addressed in this paper
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|Topics||Topics not linked to Genes||Genes linked to topics|
|Large-scale genetic interaction|
|Protein-Nucleic Acid Interactions|