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Wang X, et al.  (2007) Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. FEBS Lett 581(22):4228-34

Abstract: We report here the characterization of the yeast mto2 null mutants carrying wild-type mitochondrial DNA or 15S rRNA C1049G allele. The amounts of mitochondrial tRNA(Lys), tRNA(Glu), tRNA(Gln), tRNA(Leu), tRNA(Gly) and tRNA(Met) were markedly decreased but those of tRNA(Arg) and tRNA(His) were not affected in mto2 strains. The mto2 strains exhibited significant reduction in the aminoacylation of tRNA(Lys), tRNA(Leu) but almost no effect in those of tRNA(His). Interestingly, the strain carrying the C1049G allele exhibited an impairment of aminoacylation of those tRNAs. Furthermore, the steady-state levels of mitochondrial mRNA CYTB, COX1, COX2, COX3, and ATP6 were markedly decreased in mto2 strains. These data strongly indicate that unmodified tRNA caused by the deletion of MTO2 caused the instability of mitochondrial tRNAs and mRNAs and impairment of aminoacylation of tRNAs.

Status: Published Type: Journal Article PubMed ID: 17706197

Topics addressed in this paper

Number of different genes curated to this paper: 101

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Topics Genes linked to topics (#1 - 10 )
15S_RRNA ATP6 CDC65 COB COX1 COX2 COX3 EMT1 EMT2 EMT3
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Topics Genes linked to topics (#11 - 20 )
EMT4 EMT5 OLI1 SLM3 SOE1 SUF1 SUF16 SUF17 SUF20 SUF3
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Topics Genes linked to topics (#21 - 30 )
SUF4 SUF5 SUF6 SUP51 SUP53 SUP54 SUP56 tE(CUC)D tE(CUC)I tE(UUC)B
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Topics Genes linked to topics (#31 - 40 )
tE(UUC)C tE(UUC)E1 tE(UUC)E2 tE(UUC)E3 tE(UUC)G2 tE(UUC)G3 tE(UUC)I tE(UUC)J tE(UUC)K tE(UUC)L
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Topics Genes linked to topics (#41 - 50 )
tE(UUC)M tE(UUC)P tE(UUC)Q tG(GCC)B tG(GCC)D1 tG(GCC)D2 tG(GCC)E tG(GCC)F2 tG(GCC)G1 tG(GCC)G2
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Topics Genes linked to topics (#51 - 60 )
tG(GCC)J1 tG(GCC)J2 tG(GCC)M tG(GCC)O1 tG(GCC)P1 tG(GCC)P2 tG(UCC)Q tK(CUU)C tK(CUU)D1 tK(CUU)D2
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Topics Genes linked to topics (#61 - 70 )
tK(CUU)E1 tK(CUU)E2 tK(CUU)F tK(CUU)G1 tK(CUU)G2 tK(CUU)G3 tK(CUU)I tK(CUU)J tK(CUU)K tK(CUU)M
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Topics Genes linked to topics (#71 - 80 )
tK(CUU)P tL(CAA)D tL(CAA)G1 tL(CAA)G3 tL(CAA)K tL(CAA)L tL(CAA)M tL(CAA)N tL(GAG)G tL(UAA)B1
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Topics Genes linked to topics (#81 - 90 )
tL(UAA)B2 tL(UAA)D tL(UAA)K tL(UAA)L tL(UAA)N tL(UAA)Q tL(UAG)J tL(UAG)L1 tL(UAG)L2 tM(CAU)C
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Topics Genes linked to topics (#91 - 100 )
tM(CAU)Q1 tQ(UUG)B tQ(UUG)C tQ(UUG)D1 tQ(UUG)D2 tQ(UUG)D3 tQ(UUG)E1 tQ(UUG)E2 tQ(UUG)H tQ(UUG)L
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Topics Genes linked to topics (#101 )
tQ(UUG)Q
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