Yorimitsu T, et al. (2007) Protein Kinase A and Sch9 Cooperatively Regulate Induction of Autophagy in Saccharomyces cerevisiae. Mol Biol Cell 18(10):4180-9
Abstract: Monitoring Editor: Janet Shaw Autophagy is a highly conserved, degradative process in eukaryotic cells. The rapamycin-sensitive Tor kinase complex 1 (TORC1) has a major role in regulating induction of autophagy; however, the regulatory mechanisms are not fully understood. Here, we find that the protein kinase A (PKA) and Sch9 signaling pathways regulate autophagy cooperatively in yeast. Autophagy is induced in cells when PKA and Sch9 are simultaneously inactivated. Mutant alleles of these kinases bearing a mutation that confers sensitivity to the ATP-analog inhibitor, 1NM-PP1, revealed that autophagy was induced independent of effects on Tor kinase. The PKA-Sch9-mediated autophagy depends on the Atg1 kinase complex, which is also essential for TORC1-regulated autophagy, the transcription factors Msn2/4 and the Rim15 kinase. The present results suggest that autophagy is controlled by the signals from at least three partly separate nutrient-sensing pathways that include PKA, Sch9 and TORC1.
|Status: Published||Type: Journal Article||PubMed ID: 17699586|
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