Bao Y and Shen X (2006) Asf1, a loveseat for a histone couple. Cell 127(3):458-60
Abstract: In this issue of Cell, English et al. present the first crystal structure of a histone chaperone (Asf1) bound to histones (the H3/H4 heterodimer). The structure provides insights into how histone chaperones participate in nucleosome disassembly. It reveals that Asf1 physically blocks (H3/H4)(2) tetramer formation and that the C terminus of H4 undergoes a dramatic conformational change upon binding to Asf1.
|Status: Published||Type: Comment | Journal Article||PubMed ID: 17081967|
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