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Strub BR, et al.  (2007) Utp8p Is a Nucleolar tRNA-binding Protein That Forms a Complex with Components of the Nuclear tRNA Export Machinery in Saccharomyces cerevisiae. Mol Biol Cell 18(10):3845-59

Abstract: Monitoring Editor: Karsten Weis Utp8p is an essential nucleolar component of the nuclear tRNA export machinery in S. cerevisiae. It is thought to act at a step between tRNA maturation/aminoacylation and translocation of the tRNA across the nuclear pore complex. To understand the function of Utp8p in nuclear tRNA export, a comprehensive affinity purification analysis was conducted to identify proteins that interact with Utp8p in vivo. In addition to finding proteins that have been shown previously to copurify with Utp8p, a number of new interactions were identified. These include aminoacyl-tRNA synthetases, the RanGTPase Gsp1p, and nuclear tRNA export receptors such as Los1p and Msn5p. Characterization of the interaction of Utp8p with a subset of the newly identified proteins suggests that Utp8p most likely transfer tRNAs to the nuclear tRNA export receptors using a channelling mechanism.

Status: Published Type: Journal Article PubMed ID: 17634288

Topics addressed in this paper

Number of different genes curated to this paper: 26

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Topics Genes linked to topics (#1 - 10 )
CCA1 CRM1 GRS1 GSP1 LOS1 MSN5 NAN1 NOC4 NOP14 NOP58
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Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
NUP116 NUP170 POM152 RRS1 TYS1 UTP10 UTP13 UTP15 UTP18 UTP21
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Topics Genes linked to topics (#21 - 26 )
UTP22 UTP4 UTP5 UTP8 UTP9 VAS1
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Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball
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