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Wong J, et al.  (2007) A Protein Interaction Map of the Mitotic Spindle. Mol Biol Cell 18(10):3800-3809

Abstract: Monitoring Editor: Sandra Schmid The mitotic spindle consists of a complex network of proteins that segregates chromosomes in eukaryotes. To strengthen our understanding of the molecular composition, organization, and regulation of the mitotic spindle, we performed a system-wide two-hybrid screen on 94 proteins implicated in spindle function in S. cerevisiae. We report 604 predominantly novel interactions that were detected in multiple screens, involving 303 distinct prey proteins. We uncovered a pattern of extensive interactions between spindle proteins reflecting the intricate organization of the spindle. Furthermore, we observed novel connections between kinetochore complexes and chromatin-modifying proteins and used phosphorylation site mutants of NDC80/TID3 to gain insights into possible phospho-regulation mechanisms. We also present analyses of She1p, a novel spindle protein that interacts with the Dam1 kinetochore/spindle complex. The wealth of protein interactions presented here highlights the extent to which mitotic spindle protein functions and regulation are integrated with each other and with other cellular activities.

Status: Published Type: Journal Article PubMed ID: 17634282

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ADA2 AHC2 APC1 ASK1 BIM1 CEP3 CIN8 CKA2 CKB2 CNN1
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CPR1 CSE2 CTF19 DAD1 DAD2 DAD3 DAD4 DAM1 DEP1 DSN1
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DUO1 ESP1 HDA2 HSK3 HTA2 HTB1 IES3 IPL1 KAR3 KRE28
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Topics Genes linked to topics (#31 - 40 )
MCD1 MCM22 MED11 MED4 MED6 MED7 MED8 MIF2 MTW1 NHP10
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NKP2 NNF1 NSL1 NUF2 OKP1 PGD1 PHO23 RLF2 RXT3 SDS3
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Topics Genes linked to topics (#51 - 60 )
SGF73 SHE1 SLI15 SMC1 SNF6 SPC105 SPC19 SPC24 SPC25 SPC34
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Topics Genes linked to topics (#61 - 66 )
SRB7 STU2 SWI1 SWI3 TAF9 TID3
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