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Morton CO, et al.  (2007) An amphibian-derived, cationic, alpha-helical antimicrobial peptide kills yeast by caspase-independent but AIF-dependent programmed cell death. Mol Microbiol 65(2):494-507

Abstract: The dermaseptins are a family of antimicrobial peptides from the tree-frog Phyllomedusa sauvagii. Yeast exposed to dermaseptin S3(1-16), a truncated derivative of dermaseptin S3 with full activity, showed diagnostic markers of yeast apoptosis: the appearance of reactive oxygen species and fragmentation of nuclear DNA. This process was independent of the yeast caspase, Yca1p. Screening of a non-essential gene deletion collection in yeast identified genes that conferred resistance to dermaseptin S3(1-16): izh2Delta, izh3Delta, stm1Delta and aif1Delta, all known to be involved in regulating yeast apoptosis. The appearance of apoptotic markers was reduced in these strains when exposed to the peptide. Dermaseptin S3(1-16) was shown to interact with DNA, and cause DNA damage in vivo, a process known to trigger apoptosis. Supporting this, a dermaseptin S3(1-16) affinity column specifically purified Stm1p, Mre11p and Htb2p; DNA-binding proteins implicated in yeast apoptosis and DNA repair. Thus, amphibians may have evolved a mechanism to induce cell suicide in invading fungal pathogens.

Status: Published Type: Journal Article PubMed ID: 17587229

Topics addressed in this paper

Number of different genes curated to this paper: 23

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Topics Genes linked to topics (#1 - 10 )
AIF1 AMD1 ATS1 CSI1 FMS1 GAL2 HST3 IZH2 IZH3 MCA1
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Topics Genes linked to topics (#11 - 20 )
MPA43 PIP2 PTP3 SPO13 SRC1 STM1 YDR374C YGR126W YLL020C YLR112W
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Topics Genes linked to topics (#21 - 23 )
YLR125W YPL205C ZRC1
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