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Buzhynskyy N, et al.  (2007) Rows of ATP synthase dimers in native mitochondrial inner membranes. Biophys J 93(8):2870-6

Abstract: The ATP-synthase is a nanometric rotary machine that uses a transmembrane electrochemical gradient to form ATP. The structures of most components of the ATP synthase are known, and their organisation has been elucidated. However, the supramolecular assembly of ATP synthases in biological membranes remains unknown. Here we show with sub-molecular resolution the organisation of ATP synthases in the yeast mitochondrial inner membranes (MIM). The atomic force microscopy (AFM) images we have obtained show how these molecules form dimers with characteristic 15nm distance between the axes of their rotors through stereo-specific interactions of the membrane embedded portions of their stators. A different interaction surface is responsible for the formation of rows of dimers. Such an organisation elucidates the role of the ATP-synthase in mitochondrial morphology. Some dimers have a different morphology with 10nm stalk-to-stalk distance, in line with ATP synthases that are accessible to IF1 inhibition. Rotation torque compensation within ATP-synthase dimers stabilizes the ATP-synthase structure in particular the stator-rotor interaction.

Status: Published Type: Journal Article PubMed ID: 17557793

Topics addressed in this paper

Number of different genes curated to this paper: 29

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Topics Genes linked to topics (#1 - 10 )
ATP1 ATP10 ATP12 ATP14 ATP15 ATP16 ATP17 ATP18 ATP19 ATP2
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
ATP20 ATP22 ATP23 ATP3 ATP4 ATP5 ATP6 ATP7 ATP8 COX1
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 29 )
COX2 INH1 OLI1 QCR2 SDH1 SDH2 STF1 STF2 TIM11
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball

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