Lim HS, et al. (2007) Identification of a peptoid inhibitor of the proteasome 19S regulatory particle. J Am Chem Soc 129(25):7750-1
Abstract: The first chemical inhibitor of the 19S regulatory particle (RP) of the proteasome is described. The molecule was identified by screening a library of nucleoside-capped peptoids for binding to the yeast 26S proteasome in a crude extract. The hit was resynthesized and shown to block 19S RP-mediated protein unfolding in vitro and proteasome-mediated turnover of p27 in HeLa cells.
|Status: Published||Type: Journal Article||PubMed ID: 17536803|
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