SGD Paper 
Li L, et al. (2007) Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2. Mol Cell Biochem 304(1-2):297-304
Abstract: HCCA2 (hepatocellular carcinoma-associated gene 2) was initially identified as a HCC (hepatocellular carcinoma)-specific protein and subsequently, a long splice variant of HCCA2 was identified as a co-activator of transcription factor YY1 (Yin Yang 1). To investigate the role of HCCA2 in HCC genesis and progression, we screened a human fetal liver cDNA library and identified a novel HCCA2-interacting protein, MAD2L2 (MAD2 mitotic arrest deficient-like 2 (yeast)). The interaction between HCCA2 and MAD2L2 was confirmed by in vitro and in vivo binding assays and the interaction domain was mapped to the N-terminus of HCCA2 by sequential deletion. HCCA2 and MAD2L2 also colocalized in the nucleus of Hela cells. Furthermore, overexpression of HCCA2 led to cell cycle arrest at G0/G1 phase and therefore inhibited cell proliferation. Our research suggests that HCCA2 may play a novel role in cell cycle regulation.
| Status: Published | Type: Journal Article | PubMed ID: 17541814 |
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| Topics | Genes linked to topics |
|---|---|
| MAD2 | |
| Additional Literature |  |
| Disease Gene Related | |
| Non-Fungal Related Genes/Proteins | |
