Robishaw JD and Berlot CH (2004) Translating G protein subunit diversity into functional specificity. Curr Opin Cell Biol 16(2):206-9
Abstract: Historically, it has been assumed that the functional roles of G proteins in receptor recognition and effector regulation are specified by their diverse alpha subunits. However, the discovery of similarly diverse betagamma subunits that participate in both of these functional processes has called this assumption into question; recent work suggests that G proteins function as heterotrimers whose roles in particular receptor signaling pathways are determined by their specific alphabetagamma subunit combinations. Although much remains to be learned, the assembly of specific alphabetagamma subunit combinations seems to involve both structural and spatial factors.
|Status: Published||Type: Journal Article | Research Support, U.S. Gov't, P.H.S. | Review||PubMed ID: 15196565|
Topics addressed in this paper
Number of different genes curated to this paper: 3
- To go to the Locus page for a gene, click on the gene name.