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Baudouin-Cornu P, et al.  (2001) Molecular evolution of protein atomic composition. Science 293(5528):297-300

Abstract: Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological imprints. Significant correlations between atomic composition and metabolic function were found in sulfur- and carbon-assimilatory enzymes, which appear depleted in sulfur and carbon, respectively, in both the bacterium Escherichia coli and the eukaryote Saccharomyces cerevisiae. In addition to genetic instructions, genomic data thus also provide paleontological records of environmental nutrient availability and of metabolic costs.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 11452124

Topics addressed in this paper

Number of different genes curated to this paper: 60

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
CDC19 CYS3 CYS4 DAL1 DAL2 DAL3 DAL4 DAL5 DAL7 DAL81
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Topics Genes linked to topics (#11 - 20 )
DUR1,2 DUR3 ENO1 ENO2 FBA1 FBP1 GDH1 GDH2 GLK1 HXK1
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Topics Genes linked to topics (#21 - 30 )
HXK2 MET1 MET10 MET13 MET14 MET16 MET17 MET2 MET28 MET3
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Computational analysis blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
MET31 MET32 MET4 MET5 MET6 MET7 MET8 PDC1 PDC5 PDC6
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Topics Genes linked to topics (#41 - 50 )
PFK1 PFK2 PGI1 PGK1 PUT1 PUT2 PUT3 PUT4 PYC1 SUL1
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Topics Genes linked to topics (#51 - 60 )
SUL2 TDH1 TDH2 TDH3 TPI1 UGA1 UGA2 UGA3 UGA4 ZWF1
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Computational analysis blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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