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Gilbert RJ, et al.  (2007) Reconfiguration of yeast 40S ribosomal subunit domains by the translation initiation multifactor complex. Proc Natl Acad Sci U S A 104(14):5788-93

Abstract: In the process of protein synthesis, the small (40S) subunit of the eukaryotic ribosome is recruited to the capped 5' end of the mRNA, from which point it scans along the 5' untranslated region in search of a start codon. However, the 40S subunit alone is not capable of functional association with cellular mRNA species; it has to be prepared for the recruitment and scanning steps by interactions with a group of eukaryotic initiation factors (eIFs). In budding yeast, an important subset of these factors (1, 2, 3, and 5) can form a multifactor complex (MFC). Here, we describe cryo-EM reconstructions of the 40S subunit, of the MFC, and of 40S complexes with MFC factors plus eIF1A. These studies reveal the positioning of the core MFC on the 40S subunit, and show how eIF-binding induces mobility in the head and platform and reconfigures the head-platform-body relationship. This is expected to increase the accessibility of the mRNA channel, thus enabling the 40S subunit to convert to a recruitment-competent state.

Status: Published Type: Journal Article PubMed ID: 17389391

Topics addressed in this paper

Number of different genes curated to this paper: 80

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Topics Genes linked to topics (#1 - 10 )
ASC1 CLU1 FUN12 GCD11 HCR1 IMT1 IMT2 IMT3 IMT4 NIP1
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Topics Genes linked to topics (#11 - 20 )
PAT1 PRT1 RDN18-1 RDN18-2 RPG1 RPS0A RPS0B RPS10A RPS10B RPS11A
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Topics Genes linked to topics (#21 - 30 )
RPS11B RPS12 RPS13 RPS14A RPS14B RPS15 RPS16A RPS16B RPS17A RPS17B
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Topics Genes linked to topics (#31 - 40 )
RPS18A RPS18B RPS19A RPS19B RPS1A RPS1B RPS2 RPS20 RPS21A RPS21B
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Topics Genes linked to topics (#41 - 50 )
RPS22A RPS22B RPS23A RPS23B RPS24A RPS24B RPS25A RPS25B RPS26A RPS26B
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Topics Genes linked to topics (#51 - 60 )
RPS27A RPS27B RPS28A RPS28B RPS29A RPS29B RPS3 RPS30A RPS30B RPS31
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Topics Genes linked to topics (#61 - 70 )
RPS4A RPS4B RPS5 RPS6A RPS6B RPS7A RPS7B RPS8A RPS8B RPS9A
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Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#71 - 80 )
RPS9B SIS1 SUI1 SUI2 SUI3 TIF11 TIF34 TIF35 TIF5 YGR054W
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Protein/Nucleic Acid Structure blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

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