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Daran-Lapujade P, et al.  (2004) Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae. A chemostat culture study. J Biol Chem 279(10):9125-38

Abstract: In contrast to batch cultivation, chemostat cultivation allows the identification of carbon source responses without interference by carbon-catabolite repression, accumulation of toxic products, and differences in specific growth rate. This study focuses on the yeast Saccharomyces cerevisiae, grown in aerobic, carbon-limited chemostat cultures. Genome-wide transcript levels and in vivo fluxes were compared for growth on two sugars, glucose and maltose, and for two C2-compounds, ethanol and acetate. In contrast to previous reports on batch cultures, few genes (180 genes) responded to changes of the carbon source by a changed transcript level. Very few transcript levels were changed when glucose as the growth-limiting nutrient was compared with maltose (33 transcripts), or when acetate was compared with ethanol (16 transcripts). Although metabolic flux analysis using a stoichiometric model revealed major changes in the central carbon metabolism, only 117 genes exhibited a significantly different transcript level when sugars and C2-compounds were provided as the growth-limiting nutrient. Despite the extensive knowledge on carbon source regulation in yeast, many of the carbon source-responsive genes encoded proteins with unknown or incompletely characterized biological functions. In silico promoter analysis of carbon source-responsive genes confirmed the involvement of several known transcriptional regulators and suggested the involvement of additional regulators. Transcripts involved in the glyoxylate cycle and gluconeogenesis showed a good correlation with in vivo fluxes. This correlation was, however, not observed for other important pathways, including the pentose-phosphate pathway, tricarboxylic acid cycle, and, in particular, glycolysis. These results indicate that in vivo fluxes in the central carbon metabolism of S. cerevisiae grown in steadystate, carbon-limited chemostat cultures are controlled to a large extent via post-transcriptional mechanisms.

Status: Published Type: Journal Article | Research Support, Non-U.S. Gov't PubMed ID: 14630934

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AAD16 ACH1 ACO1 ACO2 ACS1 ACS2 ADH1 ADH2 ADH3 ADH4
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Cell Growth and Metabolism yg ball
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ADH5 AGP2 AHP1 ALD2 ALD3 ALD4 ALD5 ALD6 BAP2 CAT2
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CDA1 CDA2 CDC19 CIT1 CIT2 CIT3 COS3 COT1 CPA2 CRC1
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Topics Genes linked to topics (#31 - 40 )
CRF1 CTR3 CWP1 CYC7 DAL2 DAL5 DAL7 DCS2 DOG2 DON1
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DUR3 EAP1 ECM13 ENO1 ENO2 FBA1 FBP1 FDH1 FDH2 FIT3
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FUM1 GAD1 GCV2 GCY1 GDH3 GIP2 GLK1 GND1 GND2 GNP1
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Topics Genes linked to topics (#61 - 70 )
GOR1 GPM1 GPM2 GPM3 HMX1 HUB1 HXK1 HXK2 HXT2 HXT4
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HXT7 ICL1 ICL2 ICY1 IDH1 IDH2 IDP1 IDP2 IDP3 IGO1
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IMA1 IMA4 IMA5 INO1 ISF1 IXR1 KGD1 KGD2 LCL1 LEE1
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Topics Genes linked to topics (#91 - 100 )
LPD1 LSC1 LSC2 MAL1 MAL11 MAL12 MAL2 MAL21 MAL22 MAL31
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MAL32 MAL41 MAL42 MAL61 MAL62 MCH5 MDH1 MDH2 MDH3 MEP2
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MFA2 MLS1 MSC1 MTH1 NDE2 PCK1 PDB1 PDC1 PDC5 PDC6
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Topics Genes linked to topics (#121 - 130 )
PDH1 PDR12 PDX1 PEX21 PFK1 PFK2 PGI1 PGK1 PHM8 PIR3
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PRM4 PTI1 PYC1 PYC2 PYK2 REG2 RKI1 RPE1 RPL15B RPL31B
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Topics Genes linked to topics (#141 - 150 )
RPL7B RPS10A RPS26B RTC3 RTN2 SAM3 SDH1 SDH2 SDH3 SDH4
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SDS23 SFC1 SHH3 SIP18 SIP2 SIP4 SKG3 SKN1 SOL1 SOL2
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SOL3 SOL4 SPI1 SPS100 SPS4 SSP1 STL1 SUC2 SUC4 SWM1
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TAL1 TDA1 TDH1 TDH2 TDH3 TKL1 TKL2 TMA10 TPI1 TPO2
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TRM13 TRP4 UIP4 UPS2 VHS1 VID24 YAR068W YAR069C YAT1 YAT2
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YBR056W YBR285W YDL085C-A YDR210W YDR222W YDR248C YDR401W YEF1 YER158C YER187W
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YER188W YGP1 YGR067C YGR122C-A YGR250C YIL001W YIL014C-A YIR016W YIR043C YJL144W
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YJR115W YKL107W YKR075C YLR053C YLR108C YLR224W YLR257W YMR090W YMR315W YNL134C
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YNL190W YOL162W YPL264C YPS6 ZWF1
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