SGD Paper 
Horne WS, et al. (2007) Helix bundle quaternary structure from alpha/beta-peptide foldamers. J Am Chem Soc 129(14):4178-80
Abstract: The function of a protein generally depends on adoption of a specific folding pattern, which in turn is determined by the side chain sequence along the polypeptide backbone. Here we show that the sequence-encoded structural information in peptides derived from yeast transcriptional activator GCN4 can be used to prepare hybrid alpha/beta-peptide foldamers that adopt helix bundle quaternary structures. Crystal structures of two hybrid alpha/beta-peptides are reported along with detailed structural comparison to alpha-peptides of analogous side chain sequence. There is considerable homology between alpha- and alpha/beta-peptides at the level of helical secondary structure, with modest but significant differences in the association geometry of helices in the quaternary structure.
| Status: Published | Type: Journal Article | PubMed ID: 17362016 |
Topics addressed in this paper
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| Topics | Genes linked to topics |
|---|---|
| GCN4 | |
| Primary Literature |  |
| Protein Physical Properties | |
| Protein Sequence Features | |
| Protein/Nucleic Acid Structure | |
| Strains/Constructs | |
